BRCA1 and BRCA2 genes

The mutation of the Breast Cancer 1 (BRCA1) and Breast Cancer 2 (BRCA2) genes are known to cause cancer. 50% of children could inherit the above genetic abnormality if their parents (one or both) are diagnosed with these mutations.

The results could be positive, negative or Variant of Uncertain Significance. Our service offers a full explanation of the results together with advice and guidance about ongoing management and surveillance, depending on the outcome of the result.

Overview of the BRCA1 & BRCA2

They are tumour suppressor genes

  • Autosomal Dominant pattern, this means 50% of children have the chance of inheriting the mutated gene from any parent
  • Highly penetrant - 70-80% chance that you will manifest the disease or get the cancer.
  • More common in Jewish background.

BRCA1 & BRCA2 risks

  • Breast Cancer 1 (BRCA 1) Breast Cancer lifetime risk: 60-90%
  • Ovarian Cancer lifetime risk: 40-60%
  • Contralateral Breast Cancer lifetime risk: 50%
  • Male Breast Cancer: 0.1-1%
  • Prostate Cancer: 8% (similar to population risk)
  • Breast Cancer 2 (BRCA 2) Breast Cancer lifetime risk: 45-85%
  • Ovarian Cancer lifetime risk: 10-30%
  • Contralateral Breast Cancer lifetime risk: 50%
  • Male Breast Cancer: 5-10%
  • Prostate Cancer: 25%

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Please call / email:

+44 (0) 207 293 0317

+44 (0) 7722 275780