Please find an overview and risks of the PALB2 and CHEK2 genes.

PALB2

• Breast Cancer lifetime risk: 30-80% (varies on family history)
• Ovarian Cancer lifetime risk: 5%
• Contralateral Breast Cancer lifetime risk: varies on family history

CHEK2 (1100delC variant only)

• Breast Cancer lifetime risk: 37%
• Ovarian Cancer lifetime risk: Not significantly increased
• Possible increased risks for thyroid and Prostate Cancer Currently outside test directory and may be removed.

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+44 (0) 207 293 0317

+44 (0) 7722 275780